Archive for December, 2008

Allegra History

Tuesday, December 30th, 2008

The older antihistaminic agent terfenadine was found to metabolize into the related carboxylic acid, fexofenadine. Fexofenadine was found to retain all of the biological activity of its parent while giving fewer adverse reactions in patients, so terfenadine was replaced in the market by its metabolite.[5] Fexofenadine was originally synthesized in 1993 by Massachusetts-based biotechnology company Sepracor, which then sold the development rights to Hoechst Marion Roussel (now part of Sanofi-Aventis), and was later approved by the Food and Drug Administration (FDA) in 1996. AMRI holds the patents to the intermediates and production of fexofenadine HCl along with Roussel. Since that time, it has achieved blockbuster drug status with global sales of $1.87B USD in 2004 (with $1.49B USD coming from the United States). AMRI received royalty payments from Aventis that enabled the growth of AMRI.

Recent Reviews of Allegra

Thursday, December 18th, 2008

1. 

Positive Aspects of Allegra: 
It worked within 24 hrs.

Negative Aspects of Allegra: 
minor headache

Reason for taking Allegra:
Allergies

Additional Comments: 
This medication really help me reduce my seasonal allergies and relieve my built up congestion.

2.

Positive Aspects of Allegra:
12 hr release works within 1 hr

Negative Aspects of Allegra:
lots of back pain

Reason for taking Allegra:
seasonal allergies

Additional Comments:
The 12hr release works better for me. The 24hr passes through my system without dissolving. Maybe too much coating, not sure.
3.

Positive Aspects of Allegra:
Stops my allergies majority of the time

Negative Aspects of Allegra:
none

Reason for taking Allegra:
year round allergies

Additional Comments:
Allegra has been a blessing in my life. I have been tested by an allergist and it seems like I am allergic to almost everything. About three years ago, the MD suggested that I just take Allegra year-round and except for the beginning of spring and fall, my allergies are under control. The best part is no drowsiness.

Example of How Do Antihistamines work?

Sunday, December 7th, 2008

Let’s say that you are allergic to the perfume in a lotion, but you get
some on your skin by accident. You break out in an itchy rash where
the lotion touched your skin.

What is happening is that the perfume in the lotion caused the cells in
your body to release histamine. The histamine gets onto the surface
of your skin cells and causes an itchy rash. What do you do?

You take a dose of antihistamine such as Benadryl (diphenhydramine)
or Allegra (fexofenidine). The antihistamine acts like a bouncer. It kicks
the histamine off of the skin cells and prevents the histamine from
reacting to cause inflammation, redness and itch.

Within minutes the rash should subside and the itching go away.